What is VITAMIN B12 DEFICIENCY IN PREGNANCY?

Question

What is  VITAMIN B12 DEFICIENCY IN PREGNANCY?

Accepted Answer

Vitamin B-12 deficiency (<148 pmol/L) is associated with adverse maternal and neonatal outcomes, including developmental anomalies, spontaneous abortions, preeclampsia, and low birth weight (<2500 g) [Finkelstein JL 2015]. Pregnant women should be assessed for their risk of inadequate intake/malabsorption of vitamin B12 [Hinton CF 2010]

Disease	VITAMIN B12 DEFICIENCY IN PREGNANCY
Gene locus
ICD
Summary	Vitamin B-12 deficiency (<148 pmol/L) is associated with adverse maternal and neonatal outcomes, including developmental anomalies, spontaneous abortions, preeclampsia, and low birth weight (<2500 g) [Finkelstein JL 2015]. Pregnant women should be assessed for their risk of inadequate intake/malabsorption of vitamin B12 [Hinton CF 2010]
Laboratory findings	Methylmalonic acid inc (urine) Propionylcarnitine (C3) inc (blood)
Symptoms	abortions low birthweight (small for gestational age) onset, neonatal prematurity, premature delivery