[TREATMENT/THERAPY]: VALPROIC ACID [EXTERNAL]

Question 1

What is  [TREATMENT/THERAPY]: VALPROIC ACID [EXTERNAL]?

Accepted Answer

Valproic acid (VPA) is a widely used anticonvulsant drug which affects mitochondrial metabolism including the catabolism of fatty acids and branched-chain amino acids. 3-hydroxyisovaleric acid (3OH-IVA), one secondary metabolite of the leucine pathway, were significantly elevated in human urine after VPA treatment [Luis PB et al. 2012]

Question 2

Gibt es eine deutsche Bezeichnung?

Accepted Answer

[Therapie/Behandlung]: Valproat

Disease	[TREATMENT/THERAPY]: VALPROIC ACID [EXTERNAL]
Gene locus
ICD
Summary	Valproic acid (VPA) is a widely used anticonvulsant drug which affects mitochondrial metabolism including the catabolism of fatty acids and branched-chain amino acids. 3-hydroxyisovaleric acid (3OH-IVA), one secondary metabolite of the leucine pathway, were significantly elevated in human urine after VPA treatment [Luis PB et al. 2012]
Laboratory findings	3-Hydroxyisovaleric acid inc (urine) Glycine inc (urine) 2-Methyl-3-hydroxybutyric acid inc (urine) 3-Hydroxyisovalerylcarnitine (C5-OH) inc (plasma) Sodium normal/dec (serum)
Symptoms	hyponatremia onset, adolescent onset, childhood onset, infancy