TRANSIENT NEONATAL DIABETES MELLITUS 1

Question 1

What is  TRANSIENT NEONATAL DIABETES MELLITUS 1?

Accepted Answer

rare (1:400.000 - 1:500.000)
autosomal dominant, autosomal recessive
associated with mutation in the ZFP57 gene
imprinted gene infants develop diabetes in the first few weeks of life
remission within one and a half year

Question 2

Gibt es eine deutsche Bezeichnung?

Accepted Answer

Diabetes mellitus, neonataler transienter (1)

Question 3

What is the link to OMIM ?

Accepted Answer

OMIN 601410

Question 4

Which enzymes are involved?

Accepted Answer

Zinc finger protein 57 homolog

Disease	TRANSIENT NEONATAL DIABETES MELLITUS 1
Synonym	TNDM1
OMIM	601410 OMIM = Online Mendelian Inheritance of Men
Orphanet	99886
Protein (UniProt)	Zinc finger protein 57 homolog
Gene locus	6q24 Detail information to gene locus by the National Center for Biotechnology Information NCBI: Diabetes mellitus, transient neonatal
ICD	P70.2
Summary	rare (1:400.000 - 1:500.000) autosomal dominant, autosomal recessive associated with mutation in the ZFP57 gene imprinted gene infants develop diabetes in the first few weeks of life remission within one and a half year
Laboratory findings	D-Glucose inc (serum)
Symptoms	dehydration diabetes mellitus failure to thrive growth retardation, poor growth hyperglycemia onset, neonatal