What is HEMOCHROMATOSIS, NEONATAL?

rare autosomal recessive Gestational alloimmune liver disease (GALD) has been established as thecause of fetal liver injury resulting in nearly all cases of NH [Feldmann AG 2013]

HEMOCHROMATOSIS, NEONATAL

Disease	HEMOCHROMATOSIS, NEONATAL
Synonym	GIANT CELL HEPATITIS, NEONATAL
OMIM	231100 OMIM = Online Mendelian Inheritance of Men
Orphanet	446
Gene locus	8q21.3
ICD	E83.1
Summary	rare autosomal recessive Gestational alloimmune liver disease (GALD) has been established as the cause of fetal liver injury resulting in nearly all cases of NH [Feldmann AG 2013]
Laboratory findings	Albumin dec (serum) D-Glucose dec (blood) D-Lactic acid normal/inc (blood) Ferritin inc (serum) Hemoglobine dec (blood) Iron inc (liver) L-Tyrosine normal/inc (plasma) Methionine normal/inc (plasma) Protein, total dec (serum)
Symptoms	anemia ascites bleeding tendencies, hemorrhages cholestasis cirrhosis or fibrosis of liver Coagulopathy/Coagulation factors Coagulopathy/Coagulation factors early death encephalopathy hydrops fetalis hypoglycemia jaundice lactic acidosis liver failure liver involvement or dysfunction MRI, liver, abnormalities [-] oligohydramnion (maternal) onset, fetus onset, infancy onset, neonatal pleural effusions polyhydramnion (maternal) small for gestational age (SGA), intrauterine growth retardation (IUGR) thrombopenia, thrombocytopenia