[ARTEFACTS AND PITFALLS ]: PHARMACEUTICAL PRODUCTS, INTERFERENCE IN AMINOACID AND ORGANIC ACID ANALYSIS: ACETAMINOPHEN

Question 1

What is  [ARTEFACTS AND PITFALLS ]: PHARMACEUTICAL PRODUCTS, INTERFERENCE IN AMINOACID AND ORGANIC ACID ANALYSIS: ACETAMINOPHEN?

Accepted Answer

Pitfalls in aminoacid and organic acid analysis and skin
biopsy due to metabolites of dietary origin, medications and additives:

PARACETAMOL (ACETAMINOPHEN), reversible inhibition of glutathione synthetase, inhibition of glutathione synthetase (GS) by
N-acetyl-p-benzoquinone imine (NAPQI)?

Question 2

Gibt es eine deutsche Bezeichnung?

Accepted Answer

[Artefakte und Fallstricke]: Pharmazeutika, Interferenz Analytik von Amino- und Organischen Säuren

Question 3

Which enzymes are involved?

Accepted Answer

reversible inhibition of glutathione synthetase

Disease	[ARTEFACTS AND PITFALLS ]: PHARMACEUTICAL PRODUCTS, INTERFERENCE IN AMINOACID AND ORGANIC ACID ANALYSIS: ACETAMINOPHEN
Synonym	PITFALLS IN AMINOACID AND ORGANIC ACID ANALYSIS
Gene locus
ICD
Summary	Pitfalls in aminoacid and organic acid analysis and skin biopsy due to metabolites of dietary origin, medications and additives: PARACETAMOL (ACETAMINOPHEN), reversible inhibition of glutathione synthetase, inhibition of glutathione synthetase (GS) by N-acetyl-p-benzoquinone imine (NAPQI)?
Laboratory findings	L-Pyroglutamic acid (5-Oxoproline) inc (urine)
Symptoms	metabolic acidosis onset, adolescent onset, adulthood onset, childhood onset, infancy