ANTICONVULSANT HYPERSENSITIVITY SYNDROME : VALPROATE ASSOCIATED HEPATOTOXICITY [DD]

Question 1

What is  ANTICONVULSANT HYPERSENSITIVITY SYNDROME : VALPROATE ASSOCIATED HEPATOTOXICITY [DD]?

Accepted Answer

The pathogenesis of liver failure during VPA treatment remains unknown, the relationship between carnitine deficiency and valproate-induced hepatotoxicity is unclear

Question 2

Gibt es eine deutsche Bezeichnung?

Accepted Answer

Antikonvulsives Überempfindlichkeitssyndrom : Valproat assoziierte Lebertoxizität [DD]

Question 3

What is the link to OMIM ?

Accepted Answer

OMIN ---

Question 4

Which enzymes are involved?

Accepted Answer

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Disease	ANTICONVULSANT HYPERSENSITIVITY SYNDROME : VALPROATE ASSOCIATED HEPATOTOXICITY [DD]
Synonym	ACUTE HYPERSENSITIVITY SYNDROME: VALPROATE
OMIM	--- OMIM = Online Mendelian Inheritance of Men
Orphanet	---
ExPASy	---
Gene locus	--- Detail information to gene locus by the National Center for Biotechnology Information NCBI: MAJOR HISTOCOMPATIBILITY COMPLEX
ICD	---
Summary	The pathogenesis of liver failure during VPA treatment remains unknown, the relationship between carnitine deficiency and valproate-induced hepatotoxicity is unclear
Laboratory findings	3-Hydroxypropionic acid inc (urine) 2-n-propyl-4-pentenoic acid inc (serum) Ammonia inc (blood) Amylase inc (serum) Glycine inc (serum) L-Carnitine dec (plasma) L-Lactic acid inc (blood) Lipase inc (serum) Thrombocytes, Platelets dec (blood) Transaminases (ASAT/ALAT) inc (serum)
Symptoms	erythema multiforme fever liver failure liver involvement or dysfunction skin rash, eczematous or seborrhoic vomiting Amino acids, plasma coma dermatitis hyperammonemia lactic acidosis nausea onset, adolescent onset, childhood onset, infancy Organic acids, urine pancreatitis