8-iso-prostaglandin F2alpha

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Associated Diseases	Laboratory Findings	Clinical Symptoms
ZELLWEGER SYNDROME MIM:214100	12-Hydroxy-eicosatetraenoic acid 15-Hydroxy-eicosatetraenoic acid 8-iso-prostaglandin F2alpha Adipic acid Alkyl-dihydroxyacetone-phosphate synthase Azelaic acid Bile acid intermediates C24:0/C22:0 C26:0 C26:0/C22:0 C26:1 Dicarboxylic acids urine Dihydroxyacetone-phosphate acyltransferase (DHAPAT) EEG abnormalities [-] Iron MRI brain abnormalities [-] Peroxisomal 3-oxoacyl-CoA thiolase Peroxisomal Acyl-CoA oxidase Peroxisomal bifunctional enzyme Peroxisomes liver Phytanic acid Phytanic acid oxidation Pimelic acid Pipecolic acid Plasmalogens biosynthesis Sebacic acid Suberic acid Transaminases Very-long-chain fatty acid oxidation Very-long-chain fatty acids	birthweight low (small for gestational age) buphthalmus cataract cholestasis cirrhosis or fibrosis of liver clitoral hypertrophy congenital heart defect cryptorchism dysmorphism early death epicanthus or medial eyelid fold feeding difficulties, poor feeding glaucoma high arched palate high forehead hyporeflexia hypotonia large liver large mid-face (broad, prominent) liver failure low set ears mental retardation motor retardation nystagmus onset, newborn osteoporosis ptosis (drooping eyelid) renal cysts retinitis pigmentosa round facies (moon-face, broad) seizures shortened gestation time