bone marrow abnormality

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Associated Diseases	Laboratory Findings	Clinical Symptoms
LYSINURIC PROTEIN INTOLERANCE (LPI) MIM:222700	Ammonia Arginine Carnitine Ferritin Glutamine Hydroxyproline Lactate dehydrogenase (LDH) Lysine Ornithine Orotic acid Retikulocytes Thyroxine binding globuline (TBG)	Amino acids, urine anemia bone fractures bone marrow abnormality cataract coma diarrhea failure to thrive feeding difficulties, poor feeding growth retardation hair, abnormal (thin, brittle) hyperammonemia hypothermia hypotonia interstitial pneumonitis large liver large spleen lethargy, drowsiness, malaise or sleep disorder mental retardation neutropenia (decreased neutrophils) onset, child onset, infant onset, newborn osteoporosis pancreatitis pulmonary alveolar proteinosis renal failure, acute/chronic respiratory distress seizures spastic diplegia/quadriplegia tachypnea, hyperpnea, dyspnea, respiratory distress thrombopenia, thrombocytopenia vomiting X-ray, abnormalities