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Summary
SEPSIS, NEONATAL DD
  • antibiotics
  • supportive/symptomatic therapy
  • ventilatory support
1-4/1000 live births bacteria, viruses, fungi, protozoa serious systemic illness in the newborn may be caused by perinatal asphyxia, respiratory tract, cardiac, metabolic, neurologic, and hematologic diseases (Gotoff SP 1997)
symptoms
apnea
erythema
fever
hepatomegaly (large liver)
hypoglycemia
hypothermia
hypotonia
jaundice
lactic acidosis
metabolic acidosis
neutropenia (decreased neutrophils)
onset, neonatal
petechiae
respiratory distress
seizures
skin, infections (macules, wheals, papules, pustules)
tachypnea, hyperpnea, dyspnea, respiratory distress
thrombopenia, thrombocytopenia
vomiting
laboratory finding
CRP 10.00increasedserum
Thrombocytes, Platelets 150.00400.00decreasedblood
L-Lactic acid increasedblood
Literature
Noble-Jamieson Get al.Neurological crisis in hereditary tyrosinaemia and complete reversal after liver transplantationArch Dis Child700544-5451994
Hirschhorn RGlycogen storage disease type II: acid alpha-glucosidase (acid maltase) deficiencyThe metabolic and molecular bases of inherited disease, 7/e Editors: C.R.Scriver, A.L.Beaudet, W.S.Sly, D.Valle McGraw-Hill Inc.202443-24641995
Bonnefont JPet al.Alpha-ketoglutarate dehydrogenase deficiency presenting as congenital lactic acidosisJ Pediatr1212255-2581992