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Summary
D-LACTIC ACIDOSIS - AND SHORT BOWEL SYNDROME DD
  • antibiotics
  • low-carbohydrate diet
  • probiotics
  • sodium bicarbonate
D-lactic acidosis is a rare complication in children with short bowel syndrome or following jejuno-ileal bypass surgery, oral antibiotic-induced D-lactic acidosis with enteric overgrowth of Lactobacillus acidophilus, other forms of carbohydrate malabsorption
symptoms
ataxia
behavior, abnormal or bizarre, confusion
cardiac involvement
coma
encephalopathy
heart failure
lethargy, drowsiness, malaise or sleep disorder
metabolic acidosis
tachypnea, hyperpnea, dyspnea, respiratory distress
laboratory finding
Lactate0.000.00 increasedurineno data
Lactate0.000.00 increasedblood
Literature
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Haeberle Jet al.Congenital glutamine deficiency with glutamine synthetase mutationsN Engl J Med353181926-332005
Walker VMills GAEffects of birth asphyxia on urinary organic acid excretionBiol Neonate613162-1721992
Matuszewska Eet al.Alkaptonuria: a rare metabolic disorder. A report of two cases in siblingsPol Merkuriusz Lek1483444-4462003
Huang CCet al.Measurement of the urinary lactate:creatinine ratio for the early identification of newborn infants at risk for hypoxic-ischemic encephalopathyN Engl J Med3415328-3351999
Akisu MKultursay NValue of the urinary uric acid to creatinine ratio in term infants with perinatal asphyxiaActa Paediatr Jpn40178-811998
Demir SAlkaptonuric ochronosis: a case with multiple joint replacement arthroplastiesClin Rheumatol226437-4392003
Van Coster RNet al.Aminoacylase I deficiency: a novel inborn error of metabolismBiochem Biophys Res Commun33831322-13262005
Manoj Kumar RVRajasekaran SSpontaneous tendon ruptures in alkaptonuriaJ Bone Joint Surg Br856883-8862003
Deodato Fet al.MAMEL (METHYLMALONIC ACIDURIA MITOCHONDRIAL ENCEPHALOPATHY LEIGH-LIKE) A NEW MITOCHONDRIAL ENCEPHALOPATHYJ Inher Met Dis Suppl 12801302005
Baric Iet al.S-Adenosylhomocysteine hydrolase deficiency: A second patient, the younger brother of the index patient, and outcomes during therapyJ Inher Met Dis280885-9022005
Anders HJet al.Late Onset of Treatment with a Chemokine Receptor CCR1 Antagonist Prevents Progression of Lupus Nephritis in MRL-Fas(lpr) MiceJ Am Soc Nephrol1561504-15132004
Uyguner Oet al.Molecular analyses of the HGO gene mutations in Turkish alkaptonuria patients suggest that the R58fs mutation originated from central Asia and was spread throughout Europe and Anatolia by human migrationsJ Inherit Metab Dis26117-232003