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Summary
ANTICONVULSANT HYPERSENSITIVITY SYNDROME : VALPROATE ASSOCIATED HEPATOTOXICITY
  • L-carnitine
  • withdrawal of the drug
The pathogenesis of liver failure during VPA treatment remains unknown, the relationship between carnitine deficiency and valproate-induced hepatotoxicity is unclear
symptoms
Amino acids, plasma
coma
dermatitis
erythema multiforme
fever
hyperammonemia
lactic acidosis
liver failure
liver involvement or dysfunction
nausea
Organic acids, urine
pancreatitis
skin rash, eczematous or seborrhoic
vomiting
laboratory finding
Amylase 35.00127.00increasedserum
Glycine 230.00450.00increasedserum
3-Hydroxypropionic acid 3.0010.00increasedurine
Transaminases 10.0030.00increasedserum
L-Lactic acid 0.901.80increasedblood
2-n-propyl-4-pentenoic acid increasedserum
Ammonia 11.0032.00increasedblood
Carnitine 40.0060.00decreasedplasma
Lipase 18.0095.00increasedserum
Thrombocytes, Platelets decreasedblood
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